Do NSAID gells actually work?

[brianpugh]

Hi,



do gels such as ibuprofen gels and diclofenac gels really reduce inflamation in the joint concerned?



I'm well aware of the method of action of cox inhibitors when taken orally, but I am a little suspicious of how they are supposed to get to the joint concerned.



firstly, I a m a little cynical of just how much is absorbed through the skin - I know it uses proplyene glycol as a go-between the non-polar ibuprofen and polar nature of the skin - but how muchof it really makes it through the skin?



secondly though, if the tissues causing the inflamation are deep within the joint (eg. ligaments in the knee) surely a significant amount of the NSAID needs to get to these tissues (ie. surely it is in these tissues that the prostoglandin formation needs to be inhibited). how much of it actually makes it there?



to me - the idea that i rub it on the skin on my knee and somehow significant amounts get into the tissues of the joint seem hard to believe - what is the mechanism of transport.



I can understand how it would help if the inflamation was actually in the skin, but not when it is buried deep in a joint that is several layers of non-contiguos tissues down.



has anyone done propper double blind trials of these or better still actually measured levels in the joints?





Please Help.



Thanks,



I didn't find the right solution from the internet.

References:



www.imaginis.com/cervical-cancer



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[lipvig]

I heard essential oils such as Anise Essential Oil do help to reduce pain. Maybe you should try something like that.